姓名：张利 职称：研究员 博士生导师
通讯地址：成都市望江路29号四川大学分析测试中心432室
电 话：18030520798
E-mail:nic1976@scu.edu.cn；zhangli9111@126.com
教育及工作经历：
1996-2000年， 四川大学材料学院无机非金属材料专业，工学学士
2000-2005 年， 四川大学生物医学工程专业，工学博士
2005-2007年， 四川大学分析测试中心/纳米生物材料研究中心，讲师
2007-2014年，四川大学分析测试中心/纳米生物材料研究中心，副研究员
2014-2016年，四川大学分析测试中心/纳米生物材料研究中心，研究员
2016-2017年，加拿大多伦多大学生物材料与生物医学工程研究所，访问学者
2017-至今，四川大学分析测试中心/纳米生物材料研究中心，研究员
主要工作业绩：
主要从事生物医用材料的设计及制备、微观结构表征、结构与性能关系、体内外生物学性能评价等研究工作。作为项目负责人先后主持国家973及863项目子课题、国家自然科学基金青年及面上项目、四川省国际合作项目等，并作为主研人员参与多项国家及省部级项目研究。参与编撰英文专著《Medical Advancements in Aging and Regenerative Technologies: Clinical Tools and Applications》一部，在ACS Nano、Bioactive Materials、Small、Acta Biomaterialia、Composite B等国内外知名学术期刊发表论文130余篇；申请国家发明专利26项，授权23项。
主要研究领域/方向：
生物材料；功能材料
研究生招生专业：
1 、材料学
2 、生物医学工程
承担科研项目：
1.3D打印纳米增强网络水凝胶复合体修复替代半月板的机制研究.国家自然科学基金地区基金项目子课题（NO. 82260431），2023-2026
2.基于3D打印技术构建口腔颅颌面肿瘤性骨缺损个性化修复体的研究. 四川省国际科技合作项目（NO. 2021YFH0134），2021-2023
3.具有模量匹配和抗菌性能的牙种植体纳米复合材料体系构建及骨整合机理研究. 国家自然科学基金面上项目（No. 51673131），2017-2020
4.牙种植体表面低模量纳米材料涂层基础研究，国家973项目子课题（No.2012CB933902），2012-2016
5.三明治型人工皮肤的自剥离设计及中间层的温敏机理研究，国家自然基金青年项目（No.50903052），2010-2012
6.基于纳米复合技术的口腔引导组织再生膜和颌骨修复材料，国家863项目子课题（No.2007AA03Z328766），2008-2010
代表性科研论文（*通讯作者）
1. Lin Qi, Yong Huang, Dan Sun, Zheng Liu, Yulin Jiang, Jiangshan Liu, Jing Wang, Limin Liu, Ganjun Feng*, Yubao Li*, and Li Zhang*. Guiding the path to healing: CuO2-laden nanocomposite membrane for diabetic wound treatment. Small. 2023, Doi: 10.1002/smll.202305100
2. Ruibang Wu, Leizhen Huang, Qinghong Xia, Zheng Liu, Yong Huang, Yulin Jiang, Juehan Wang, Hong Ding, Ce Zhu, Yueming Song, Limin Liu*, Li Zhang*, Ganjun Feng*. Injectable mesoporous bioactive glass/sodium alginate hydrogel loaded with melatonin for intervertebral disc regeneration. Mater Today Bio. 2023, 22: 100731
3. Yulin Jiang, Juehan Wang, Ruibang Wu, Lin Qi, Leizhen Huang, Jing Wang, Meixuan Du, Zheng Liu, Yubao Li, Limin Liu*, Ganjun Feng*, Li Zhang*. Bioinspired construction of annulus fibrosus implants with a negative Poisson’s ratio for intervertebral disc repair and restraining disc herniation. Bioconjug Chem. 2023, 34: 789-798
4. Zheng Liu, Hong Ding, Miaomiao He, Yulin Jiang, Lin Qi, Meixuan Du, Jing Wang, Yubao Li, Limin Liu, Ganjun Feng*, Li Zhang*. Construction of a Ni(OH)2@CaTiO3 heterostructure on a Ti implant for enhanced osseointegration through NIR photoactivated bacterial inactivation and microenvironment optimization. Nanoscale. 2023, 15: 9148
5. Yulin Jiang, Juehan Wang, Dan Sun, Zheng Liu, Lin Qi, Meixuan Du, Jing Wang, Yubao Li, Ce Zhu, Yong Huang, Yueming Song, Limin Liu*, Ganjun Feng*, Li Zhang*. A hydrogel reservoir as a self-contained nucleus pulposus cell delivery vehicle for immunoregulation and repair of degenerated intervertebral disc. Acta Biomaterialia. 2023, Doi:10.1016/j.actbio.2023.08.023
6. Yong Huang, Lin Qi, Zheng Liu, Yulin Jiang, Jing Wang, Limin Liu, Yubao Li*, Li Zhang*, Ganjun Feng*. Radially electrospun fibrous membrane incorporated with copper peroxide nanodots capable of self-catalyzed chemodynamic therapy for angiogenesis and healing acceleration of diabetic wounds. ACS Appl Mater Interfaces. 2023, 15: 35986
7. Yi Hou, Mengmeng Jin, Dan Sun, Junfeng Li, Ruiye Bi, Li Zhang*, Songsong Zhu*. Multifunctional inorganic/organic nanocomposite microspheres – reinventing eggs for bone repair applications. Composite Part B. 2023, 255: 110644
8. Yi Hou, Mengmeng Jin, Yao Liu, Nan Jiang, Li Zhang, Songsong Zhu*. Biomimetic construction of a lubricious hydrogel with robust mechanics via polymer chains interpenetration and entanglement for TMJ disc replacement. Chem Eng J. 2023, 460: 141731
9. Hong Ding, Xiang Zhang, Zheng Liu, Juehan Wang, Ce Zhu, Qian Chen, Yong Huang, Youwei Ai, Ruibang Wu, Ganjun Feng*, Li Zhang*, Limin Liu*. Construction of MOFs nanoplatform with pH-triggered release of protocatechuic acid for intervertebral disc degeneration therapy. Materials & Design. 2023, 225: 111493
10. Yulin Jiang, Kun Shi, Luonan Zhou, Miaomiao He, Ce Zhu, Jingcheng Wang, Jianhua Li, Yubao Li, Limin Liu, Dan Sun, Ganjun Feng*, Yong Yi, Li Zhang*. 3D-printed auxetic-structured intervertebral disc implant for potential treatment of lumbar herniated disc. Bioactive Materials. 2023, 20: 528
11. Miaomiao He, Ce Zhu, Dan Sun, Zheng Liu, Meixuan Du, Yong Huang, Leizhen Huang, Juehan Wang, Limin Liu, Yubao Li, Yueming Song, Gnajun Feng*, Li Zhang*. Layer-by-layer assembled black phosphorus/chitosan composite coating for multi-functional PEEK bone scaffold. Composites Part B. 2022, 246:110266
12. Yi Zhuang, Zhaojun Kan, Yulin Jiang, Miaomiao He, Yuanyuan Zhang, Xiaodong Sun, Meixuan Du, Jing Wang, Yubao Li, Yunfeng Li*, and Li Zhang*. Constructing an on-demand drug release system composed of thermosensitive PPP hydrogel and drug-laden alginate/graphene microspheres to treat tumorous defect. J Mater Sci. 2022, 57: 4754
13. Ce Zhu, Miaomiao He, Dan Sun, Yong Huang, Leizhen Huang, Meixuan Du, Jingcheng Wang, Juehan Wang, Zhongyang Li, Bowen Hu, Yueming Song, Yubao Li, Ganjun Feng,* Limin Liu,* and Li Zhang*. 3D-Printed Multifunctional Polyetheretherketone Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis. ACS Appl Mater Interfaces. 2021, 13: 47327
14. Miaomiao He, Yong Huang, Huan Xu, Ganjun Feng, Limin Liu, Yubao Li, Dan Sun*, Li Zhang*. Modification of polyetheretherketone implants: From enhancing bone integration to enabling multi-modal therapeutics. Acta Biomaterialia. 2021, 129: 18
15. Bianyun Cai, Leizhen Huang, Jingcheng Wang, Dan Sun, Ce Zhu, Yong Huang, Shujun Li, Zhijun Guo, Limin Liu, Ganjun Feng,* Yubao Li,* and Li Zhang*. 3D Printed Multifunctional Ti6Al4V Based Hybrid Scaffold for the Management of Osteosarcoma. Bioconjug Chem. 2021, 32 (10): 2184
16. Meiling He, Yi Hou, Ce Zhu, Miaomiao He, Yulin Jiang, Ganjun Feng, Limin Liu, Yubao Li, Chen Chen,* and Li Zhang*. 3D-Printing Biodegradable PU/PAAM/Gel Hydrogel Scaffold with High Flexibility and Self-Adaptibility to Irregular Defects for Nonload-Bearing Bone Regeneration. Bioconjug Chem, 2021, 32:1915
17. Meixuan Du, Miaomiao He, Ce Zhu, Zheng Liu, Yulin Jiang, Yi Zhuang, Yubao Li, Ganjun Feng,* Limin Liu, and Li Zhang*. Endowing Conductive Polyetheretherketone/Graphene Nanocomposite with Bioactive and Antibacterial Coating through Electrophoresis. Macromol Mater Eng. 2021, 2100246
18. Leizhen Huang, Bianyun Cai, Yong Huang, Jingcheng Wang, Ce Zhu, Kun Shi, Yueming Song, Ganjun Feng,* Limin Liu,* and Li Zhang*. Comparative Study on 3D Printed Ti6Al4V Scaffolds with Surface Modifications Using Hydrothermal Treatment and Microarc Oxidation to Enhance Osteogenic Activity. ACS Omega. 2021, 6: 1465-1476
19. Miaomiao He, Ce Zhu, Huan Xu, Dan Sun, Chen Chen, Ganjun Feng, Limin Liu, Yubao Li, Li Zhang*. Conducting PEEK Nanocomposites with Electrophoretically Deposited Bioactive Coating for Bone Tissue Regeneration and Multi-Modal Therapeutic Applications. ACS Appl Mater Interfaces. 2020, 12: 56924-56934.
20. Miaomiao He, Feiyang Ou, Yue Wu, Xiaodong Sun, Xianchun Chen, Han Li, Dan Sun*, Li Zhang*. Smart multi-layer PVA foam/CMC mesh dressing with integrated multi-functions for wound management and infection monitoring. Materials & Design. 2020, 194: 108913
21. Bianyun Cai, Peijie Tan, Nan Jiang, Zhijun Guo, Shujun Li, Yi Hou, Yubao Li, Yanjun You, Li Zhang*, and Songsong Zhu*. Bioinspired fabrication of calcium-doped TiP coating with nanofibrous microstructure to accelerate osseointegration. Bioconjug Chem. 2020, 31: 1641
22. Yi Hou, Ying Song, Xiaodong Sun, Yulin Jiang, Meiling He, Yubao Li, Xianchun Chen*, Li Zhang*. Multifunctional Composite Hydrogel Bolus with Combined SelfHealing, Antibacterial and Adhesive Functions for Radiotherapy. J Mater Chem B. 2020, 8: 2627
23. Yulin Jiang, Yutao Yang, Xiaoyang Zheng, Yong Yi, Xianchun Chen, Yubao Li, Dan Sun*, Li Zhang*. Multifunctional load-bearing hybrid hydrogel with combined drug release and photothermal conversion functions. NPG Asia Materials. 2020, 12:18
24. Yi Hou, Nan Jiang, Dan Sun*, Yiping Wang, Xianchun Chen, Songsong Zhu*, Li Zhang*. A fast UV-curable PU-PAAm hydrogel with mechanical flexibility and self-adhesion for wound healing. RSC Advances, 2020, 10:4907
25. Bianyun Cai, Nan Jiang, Peijie Tan, Yi Hou, Yubao Li*, Li Zhang*, Songsong Zhu*. The custom making of hierarchical micro/nanoscaled titanium phosphate coatings and their formation mechanism analysis. RSC Advances. 2019, 9: 41311
26. Zhijun Guo, Nan Jiang, Jessica Moore, Colin P. McCoy, Monika Ziminska, Cormac Rafferty, Gianluca Sarri, Andrew R. Hamilton, Yubao Li, Li Zhang, Songsong Zhu and Dan Sun. Nanoscale Hybrid Coating Enables Multifunctional Tissue Scaffold for Potential Multimodal Therapeutic Applications. ACS Appl Mater Interfaces. 2019, 11: 27269
27. Daye Sun, James McLaughlan, Li Zhang, Brian G. Falzon, Davide Mariotti, Paul Maguire, and Dan Sun. Atmospheric Pressure Plasma-Synthesized Gold Nanoparticle/Carbon Nanotube Hybrids for Photothermal Conversion. Langmuir. 2019, 35: 4577
28. Nan Jiang, Zhijun Guo, Dan Sun, Birol Ay, Yubao Li, Yutao Yang, Peijie Tan, Li Zhang*, Songsong Zhu*. Exploring the mechanism behind improved osteointegration of phosphorylated titanium implants with hierarchically structured topography. Colloids and Surfaces B. 2019, 184: 110520
29. Miaomiao He, Xianchun Chen, Zhijun Guo, Xiaotao Qiu, Yutao Yang, Chengli Su, Nan Jiang, Yubao Li, Dan Sun*, Li Zhang*. Super tough graphene oxide reinforced polytheretherketone for potential hard tissue repair applications. Compos Sci Technol. 2019, 174: 194
30. Yulin Jiang, Yi Deng, Ying Tu, Birol Ay, Xiaodogn Sun, Yubao Li, Xiaohong Wang, Xianchun Chen*, Li Zhang*. Chitosan-based asymmetric topological membranes with cell-like features for healthcare applications. J Mater Chem B. 2019, 7: 2634
31. Yi Deng, Min Huang, Dan Sun, Yi Hou, Yubao Li, Taosheng Dong, Xiaohong Wang, Li Zhang*, Weizhong Yang*. Dual physically crosslinked k-carrageenan-based double network hydrogels with superior self-healing performance for biomedical application. ACS Appl Mater Interfaces. 2018, 10(43): 37544
32. Nan Jiang, Zhijun Guo, Dan Sun, Yubao Li, Yutao Yang, Chen Chen, Li Zhang* and Songsong Zhu*. Promoting Osseointegration of Ti Implants through Micro/nano-scaled Hierarchical Ti Phosphate / Ti Oxide Hybrid Coating. ACS Nano. 2018, 12: 7883
33. Xin Lai, Dan Sun, Yi Hou, Yi Zuo, Yubao Li and Li Zhang*. Amino-functionalized multi-layer core-shell mesoporous organosilica nanospheres for Cr(VI) removal. Adv Mater Interfaces. 2018, 5:1800630
34. Chen Chen, Xiaodong Sun, Wu Pan, Yi Hou, Rui Liu, Xin Jiang and Li Zhang*. Graphene Oxide-Templated Synthesis of Hydroxyapatite Nanowhiskers To Improve the Mechanical and Osteoblastic Performance of Poly(lactic acid) for Bone Tissue Regeneration. ACS Sustain Chem Eng. 2018, 6: 3862
35. Hou Yi, Jiang Nan, Zhang Li*, Li Yubao, Meng Yuezhong, Han Dongmei, Chen Chen, Yang Yuan and Zhu Songsong*. Oppositely charged polyurethane microspheres with tunable Zeta potentials as an injectable dual-loaded system for bone repair. ACS Appl Mater Interfaces. 2017, 9: 25808
36. Zhijun Guo, Nan Jiang, Chen Chen, Songsong Zhu, Li Zhang* and Yubao Li*. Surface bioactivation through the nanostructured layer on titanium modified by facile HPT treatment. Scientific Report. 2017, 7:4155
部分授权发明专利
1. 张利，刘浩怀，李玉宝，聚氨酯医用复合膜及制备方法，申请号：200810046484.8，申请日：2008.10.7， 授权日：2012.9.19
2. 张利，李砚，李玉宝，含有聚氮异丙基丙烯酰胺成分的复合材料膜及制备方法，申请号：200910058380.3，申请日：2009.2.19
3. 张利，李勤奋，黄棣，李玉宝，侯先文，邓晓. 土壤治理用的复合材料及制备方法.发明专利，申请号：200910216257.x. 授权日：2011.6.15
4. 张利，张熠，李勤奋，李光义，侯先文. 智能高吸水保水材料与制备方法及在沙漠化治理中的应用. 申请号：201010509589.x. 授权日：2012.7.11
5. 张利，龚梅，李玉宝. 人工皮肤替代材料及制备方法. 申请号：201210040044.8，申请日：2012.2.22，授权日：2014.4.9
6. 张利，胡盼，李玉宝，王立军，周名兵，胡静. 智能可控释放抗菌成分的牙种植体及制备方法. 申请号：201210348628.1，申请日：2012.9.19，授权日：2015.2.25
7. 张利，王立军，李玉宝，龚梅，胡盼，胡静，李继华. 一种仿生牙种植体及其制备方法. 申请号：201210384731.1，申请日：2012.10.7，授权日：2014.6.11
8. 张利，龚梅，李玉宝. 一种用于美容填充的微球组织工程支架及其制备方法. 申请号：201310008187.5，申请日：2013.1.9，授权日：2014.5.7
9. 张利，郭志君，李玉宝. 具有微米-纳米粗糙结构表面的钛或钛合金材料及制备方法. 申请号：ZL 201410000589.5，申请日：2014.1.2，授权日：2016.10.26
10. 张利，侯毅，李玉宝，涂英，郭志君. 一种纤维增强型载药水凝胶人工角膜裙边支架及其制备方法. 申请号：ZL201410631847.x，申请日：2014.11.10，授权日：2016.1.13
11. 张利，涂英，李玉宝. 一种聚醚醚酮/纳米羟基磷灰石牙种植体及其制作方法.申请号：201510345421.2，申请日期：2015.6.19，授权日：2017.5.31
12. 张利，熊鑫，李玉宝. 改性卡拉胶-壳聚糖聚电解质微球及其制备方法和用途. 申请号：201610891001.9，申请日：2016.10.12, 授权日：2018.10.30
13. 祝颂松，江雨林，张利，姜楠，侯毅，胡浩哲. 一种基于三维网络支架的高强度水凝胶及其制备方法. 专利号：ZL 2018 1 0455155.2，授权日：2020.6.2
14. 张利，侯毅.基于聚氨酯的喷射型光固化水凝胶敷料前驱液及制备方法.ZL 201910342528.x，授权日：2020.7.14
15. 毕瑞野，何苗苗，张利，李玉宝，祝颂松，丰干钧，刘立岷，朱策. 具有骨修复和抑制肿瘤功能的复合材料及其制备方法. 专利号：201911299595.4，申请日：2019.12.16， 授权日：2021.9.14
16. 毕瑞野，何苗苗，张利. 具有光热转换性能和功能涂层的骨修复和肿瘤抑制材料及制备方法. 专利号：201911321696.7，申请日：2019.12.16，授权日：2021.5.21
17. 张利，何苗苗，郭涛. 兼具抗菌和带菌警示功能的伤口敷料及其制备方法. 专利号：ZL 202010321217.8, 申请日：2020.4.21，授权日：2022.4.19
18. 张利，何苗苗.工程塑料和多孔金属板的层压复合材料及其制备方法.专利号：202110169711.1，申请日：2021.2.8
