唐娅楠 特聘副研究员

通讯地址：成都市望江路29号四川大学分析测试中心 邮编：610064

电话：028-85412950 (Office)

E-mail:yanantang@scu.edu.cn

学习工作经历：

2019-至今，四川大学分析测试中心，特聘副研究员

2016-2019，加拿大多伦多病童医院，助理研究员

2015-2016，加拿大NorthernChem Inc.分析部，经理

2013-2014，加拿大阿尔伯塔大学化学系、环境毒理及分析室，博士后

2007-2013，加拿大阿尔伯塔大学化学系，博士

2002-2006，四川大学华西药学院，本科

研究兴趣：

1. 以质谱分析为研究手段，对生物样品、临床样品及环境样品等复杂样品进行高特异性、高灵敏度、高通量的组学分析。研究重大疾病发生发展的分子机理，寻找具有临床意义的疾病分子标记物。探索环境污染物诱发的生物信号通路变化，揭示环境污染物与疾病发生发展的关系。

2. 以DNA探针和纳米机器为基础，研发针对疾病分子标记物的超灵敏检测手段。

近期代表论文：

1.Yongya Li, Guan A. Wang, Sean D. Mason, Xiaolong Yang, Zechen Yu,Yanan Tang, Feng Li,“Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants”,Chemical Science, 2018,9, 6434-6439.

2.Xiaolong Yang*,Yanan Tang*,Ryan R. Alt,Xiaoyu XieandFeng Li, “Emerging Techniques for Ultrasensitive Protein Analysis”,Analyst,2016, 141, 3473-3481 (* These authors contributed equally to this paper).

3.Yanan Tang, Ying Xu, Feng Li, Lindsay Jmaiff, Steve E Hrudey, Xing-Fang Li, “Nontargeted Identification of Peptides and Disinfection Byproducts in Water”,J. Environ. Sci.,2016, 42, 259-266

4.Yanan Tang, Feng Li, Guang Huang, Xing-Fang Li,“Mass Spectrometry Analysis of Peptides distributed in Environment”,Encyclopedia of Analytical Chemistry,2016.DOI: 10.1002/9780470027318.a9570. (Invited Contribution)

5.XiaolongYang,YananTang, Sarah M. Traynor,Feng Li, “Regulation of DNA Strand Displacement Using Allosteric DNA Toehold”,J. Am. Chem. Soc., 2016,138 (42), pp 14076–14082

6.XiaolongYang,YananTang, SeanMason,JunboChen,Feng Li, “Enzyme-powered three dimensional DNA nanomachine for DNA walking, payload release, and biosensing”,ACS Nano, 2016, 10, 2324-2330.

7.Feng Li,Yanan Tang, Sarah M. Traynor, Xing-Fang Li, X. Chris Le, “Kinetics of Proximity-Induced Intramolecular DNA Strand Displacement”,Anal. Chem.,2016, 88 (16), 8152-8157.

8.Yanan Tang, Zhixin Wang, Junbo Chen, Linan Liu, Weian Zhao, X. Chris Le, Feng Li, “Construct Real-Time, Wash-Free, and Reiterative Sensors for Cell Surface Proteins Using Binding-Induced Dynamic DNA Assembly”,Chem. Sci.,2015,6, 5729-5733

9.Yanan Tang, Yanwen Lin, Xiaolong Yang, Zhixin Wang, X. Chris Le, Feng Li, “A Universal Strategy to Engineer Catalytic DNA Hairpin Assemblies for Protein Analysis”,Anal. Chem.,2015,87, 8063-8066

10.Yanan Tang, Ronghong Li, Guohui Lin, Liang Li, “PEP Search in MyCompoundID: Detection and Identification of Dipeptides and Tripeptides in Biological Samples Using Dimethyl Labeling and Hydrophilic Interaction Liquid Chromatography Tandem Mass Spectrometry”,Anal. Chem., 2014, 86 (7), 3568–3574

11.Yanan Tang, Liang Li, “Differential Isotope Dansylation Labeling Combined with Liquid Chromatography Mass Spectrometry for Quantification of Intact and N-terminal Truncated Proteins”,Anal. Chim. Acta., 2013, 792, 79-85

12.Yanan Tang, John Mackey, Raymond Lai, Sunita Ghosh, Cheryl Santos, Kathryn Graham, Sambasivarao Damaraju, Manijeh Pasdar, Liang Li, “Quantitative Proteomic Analysis of HER2 Normal and Overexpressing MCF-7 Breast Cancer Cell Line by Mass Spectrometry”,J.Proteomics., 2013, 91, 200-209